Catecholamine
Catecholamine (6 Items)
Catecholamine Acid Metabolite (3 Items)
Sample Release Agent (Plate Method) Liquid Chromatography
Sample Extract (Magnetic Bead Method) Tandem Mass Spectrometry
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DETECTION INDICATOR |
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Noradrenaline, epinephrine, dopamine, methoxynorepinephrine, metanephrines, 3-methoxytyramine, vanilmandelic acid, 5-hydroxyindoleacetic acid, homovanillic acid |
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CLINICAL APPLICATION |
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The sample is used for laboratory auxiliary examination of diseases such as hypercatecholaminism, pheochromocytoma, paraganglioma, neuroblastoma, hypertension, myocardial infarction, adrenal medulla hyperplasia, etc. |
Recommendation: Determination of catecholamine is preferred using liquid chromatography tandem mass spectrometry (LC-MS/MS) (1|••••). Pheochromocytoma (PCC) is a neuroendocrine tumor originating from the adrenal medulla, paraganglioma (PGL) is a neuroendocrine tumor originating from the sympathetic chain outside the adrenal gland and having hormone secretion function, which mainly synthesizes, secretes and releases large amounts of catecholamine, such as NE, E and DA, causing a series of clinical syndromes such as elevated blood pressure and metabolic changes in patients, and causing serious complications such as heart, brain, kidney and blood vessels or even becoming the main cause of patient death. PCC tumors are located in the adrenal gland and PGL tumors are located in the paravertebral sympathetic chain of the chest, abdomen and pelvis, both of which are collectively referred to as PPGL.
-From Expert Consensus on the Diagnosis and Treatment of Pheochromocytoma and Paraganglioma (2020 Edition)
