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Water-Soluble Vitamin Liquid Chromatography

Sample Release Agent (Plate Method)… Tandem Mass Spectrometry

DETECTION INDICATOR

Vitamin B₁, vitamin B₂, vitamin B₃, vitamin B₅, vitamin B₆, vitamin B₇, vitamin B₉, vitamin B₁₂, vitamin

CLINICAL APPLICATION

The sample is used for laboratory auxiliary examination of diseases with abnormal water-soluble vitamin content in human body, such as fetal neural tube defects, pernicious anemia, scurvy, etc.

Overdose		Lack
Headache, vertigo, irritability	Vitamin B₁	Wernicke encephalopathy, beriberi
Tubular obstruction	Vitamin B₂	Growth retardation, angular cheilitis, conjunctivitis
Hepatic lesion, skin erythema	Vitamin B₃	Fetal congenital heart disease, bark favus, oral inflammation
Neuritis	Vitamin B₅	Decreased blood pressure, nausea, vomiting, loss of appetite, diarrhea, insomnia, hypoglycemia
Fetal nanomelia and sensory peripheral neuropathy	Vitamin B₆	Dermatitis, acne, anemia, chronic diarrhea
No toxicity has been reported	Vitamin B₇	Dermatitis, eczema, glossitis, myalgia, lethargy, anorexia, anemia, alopecia
Fetal developmental retardation, low birth weight, zinc deficiency in pregnant women	Vitamin B₉	Fetal neural tube defects, congenital cleft lip and palate, megaloblastic anemia
Fetal nanomelia, neurosensory dysfunction, increased liver and kidney burden	Vitamin B₁₂	Pernicious anaemia, hyperhomocysteinaemia, methylmalonic aciduria
Pediatric bone disease, lithiasis, gout, nausea	Vitamin C	Scurvy, pediatric purpura, hemorrhage in pregnancy